Carcinomas of the Urethra – Urethrectomy Specimen

2nd edition – December 2025

Updated following the publication of the 2022 World Health Organization (WHO) Classification of Urinary and Male Genital Tumours, 5th edition.

This 2nd edition dataset was developed with the kind support of the International Society of Urological Pathology (ISUP).

SUMMARY OF CHANGES

• Updated to Union for International Cancer Control TNM9 staging, including errata published October 2025.
• Revised guide to harmonise with ICCR style for element titles and value list.
• Revised scope for clarity and to harmonise with ICCR style.
• Updated the ‘Clinical information’ element.
• Renamed the ‘Macroscopic tumour site’ element ‘Tumour site’ and updated.
• Renamed the ‘Maximum tumour dimension’ element ‘Tumour dimensions’ and changed to a non-core element.
• ‘Macroscopic extent of invasion’ was changed to a non-core element and updated.
• Updated the ‘Histological tumour type’ element to the 5th edition WHO Classification of Urinary and Male Genital Tumours.
• Updated the ‘Non-invasive carcinoma’ element.
• Updated the ‘Histological tumour grade’ element.
• Updated the ‘Microscopic extent of invasion’ element.
• Renamed the ‘Regional lymph node status’ element ‘Lymph node status’ and updated.
• Expanded the ‘Ancillary studies’ element, including adding ‘Representative blocks for ancillary studies’.
• Other minor updates to elements were also included.
• Revised all notes, including incorporation of the 5th edition WHO Classification of Urinary and Male Genital Tumours.

• To reference this dataset please use the following citation: Tsuzuki T, Compérat E, Baydar DE, Cheng L, de Santis M, Downes MR, Hansel DE, Hartmann A, Lopez-Beltran A, Nishiyama H, Ohe C, Pan CC, Reuter VE, Stenzl A, Varma M, Srigley JR (2025). Carcinoma of the Urethra Histopathology Reporting Guide – Urethrectomy Specimen. 2nd edition. International Collaboration on Cancer Reporting; Sydney, Australia. ISBN: 978-1-922324-76-4.

1st edition – May 2018

• To reference this dataset please use the following citation: Grignon D, Brimo F, Comperat E, Delahunt B, Koch M, Lopez-Beltran A, Reuter V, Samaratunga H, Shanks J, Tsuzuki T, van der Kwast T, Varma M, Srigley JR (2018). Carcinoma of the Urethra Histopathology Reporting Guide – Urethrectomy Specimen. 1st edition. International Collaboration on Cancer Reporting; Sydney, Australia. ISBN: 978-1-925687-15-6.

• ​Read more on the Carcinoma of the urethra – urethrectomy specimen dataset from the journal article written by the dataset authors: Dataset for reporting of carcinoma of the urethra (in urethrectomy specimens): recommendations from the International Collaboration on Cancer Reporting (ICCR). Shanks JH, Srigley JR, Brimo F, Comperat E, Delahunt B, Koch M, Lopez-Beltran A, Reuter V, Samaratunga H, Tsuzuki T, van der Kwast T, Varma M, Grignon D. Histopathology. 2019 Oct;75(4):453-467. doi: 10.1111/his.13877. Epub 2019 Jul 2.

The 2nd edition of the dataset for Carcinoma of the urethra – urethrectomy specimen was developed by the following international team:

• Co-chair – Toyonori Tsuzuki, Japan
• Co-chair – Eva Compérat, Austria
• Series Champion and ICCR representative – John Srigley, Canada

Domain experts:

• Dilek Ertoy Baydar, Turkey
• Liang Cheng, USA
• Maria de Santis, Germany
• Michelle Downes, Canada
• Donna Hansel, USA
• Arndt Hartmann, Germany
• Antonio Lopez-Beltran, Portugal
• Hiroyuki Nishiyama. Japan
• Chisato Ohe, Japan
• Chin-Chen Pan, Taiwan
• Victor Reuter USA
• Arnulf Stenzl, Germany
• Murali Varma, UK

Authors of previous edition of this dataset are available here.