The dataset has been developed for the pathological reporting of biopsy and resection specimens of paediatric peripheral neuroblastic tumours.

Most such tumours in adults are benign ganglioneuromas; there is a paucity of evidence to support classification and treatment guidelines of neuroblastomas and ganglioneuroblastomas in patients over 10 years old due to their rarity.

Treatment, especially traditional chemotherapy and radiotherapy, can alter the histologic appearance and composition of neuroblastic tumours. These changes may or may not reflect the original classification of the tumour or its original or future biologic behaviour. Thus, much of this dataset is not suitable for use with post-treatment tumours.

In those rare cases where more than one primary tumour is present, separate datasets should be completed for each neoplasm.

Publication History

This dataset was developed with the kind support of the International Paediatric Pathology Association (IPPA), Paediatric Pathology Society (PPS) and Society for Pediatric Pathology (SPP).

1st edition – November 2023

  • To reference this dataset please use the following citation: Jarzembowski JA, Beiske K, Cohn SL, de Krijger RR, Irwin MS, Navarro S, Okita H, Shimada H, Stahlschmidt J, Vokuhl C, Wang LL, Cohen M, Reyes-Múgica M (2023). Neuroblastoma Histopathology Reporting Guide. 1st edition. International Collaboration on Cancer Reporting; Sydney, Australia. ISBN: 978-1-922324-39-9.

Expert Committee

The 1st edition of the dataset for Neuroblastoma was developed by the following international team:

  • Chair – Jason A Jarzembowski, USA
  • Series Champion – Miguel Reyes-Múgica, USA
  • ICCR representative – Marta Cohen, UK

Domain experts:

  • Klaus Beiske, Norway
  • Susan L Cohn, USA
  • Ronald R de Krijger, The Netherlands
  • Meredith S Irwin, Canada
  • Samuel Navarro, Spain
  • Hajime Okita, Japan
  • Hiro Shimada, USA
  • Jens Stahlschmidt, UK
  • Christian Vokuhl, Germany
  • Larry L Wang, USA
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