Phaeochromocytoma and Paraganglioma

2nd edition – November 2025

Updated following the publication of the 2025 World Health Organization (WHO) Classification of Endocrine and Neuroendocrine Tumours, 5th edition.

SUMMARY OF CHANGES

• Updated to Union for International Cancer Control TNM9 staging, including errata published October 2025.
• Revised guide to harmonise with ICCR style for element titles and value list.
• Revised scope for clarity and to harmonise with ICCR style.
• Updated the ‘Clinical information’ element.
• Updated the ‘Specimen(s) submitted’ element.
• Added a new non-core element ‘Block identification key’.
• Removed the element ‘Medullary hyperplasia’.
• Updated the ‘Histological tumour type’ element.
• Added a new core element ‘Tumour necrosis’.
• Updated the ‘Lymphovascular invasion’ element.
• Updated the ‘Margin status’ element.
• Renamed the ‘Adverse features’ element to ‘Adverse histological features’ and updated.
• Updated the ‘Ancillary studies’ element, including adding ‘Representative blocks for ancillary studies’ as non-core.
• Other minor updates to elements were also included.
• Revised all notes, including incorporation of the 5th edition WHO Classification of Endocrine and Neuroendocrine Tumours.

• To reference this dataset please use the following citation: de Krijger RR, Asa SL, Kimura N, Moonim MT, Oudijk L, Sadow PM. Thompson LDR, Tischler AS, Valk GD, Lax SF, Gill AJ (2025). Phaeochromocytoma and Paraganglioma Histopathology Reporting Guide. 2nd edition. International Collaboration on Cancer Reporting; Sydney, Australia. ISBN: 978-1-922324-70-2.

1st edition – December 2019

• To reference this dataset please use the following citation: Tischler A, Asa S, Clifton-Bligh R, de Krijger R, Kimura N, Komminoth P, Lack E, Lenders J, Lloyd R, Papathomas T, Sadow P, Thompson L, Gill A (2019). Phaeochromocytoma and Paraganglioma Histopathology Reporting Guide. 1st edition. International Collaboration on Cancer Reporting; Sydney, Australia. ISBN: 978-1-925687-28-6.

• Read more on the Phaeochromocytoma and paraganglioma dataset from the journal article written by the dataset authors: Data set for the reporting of pheochromocytoma and paraganglioma: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. Thompson LDR, Gill AJ, Asa SL, Clifton-Bligh RJ, de Krijger RR, Kimura N, Komminoth P, Lack EE, Lenders JWM, Lloyd RV, Papathomas TG, Sadow PM, Tischler AS. Hum Pathol. 2021 Apr;110:83-97. doi: 10.1016/j.humpath.2020.04.012. Epub 2020 May 11.

The 2nd edition of the dataset for Phaeochromocytoma and paraganglioma was developed by the following international team:

• Chair – Ronald de Krijger, The Netherlands
• Series Champion – Anthony Gill, Australia
• ICCR representative – Sigurd Lax, Austria

Domain experts:

• Sylvia Asa, USA
• Noriko Kimura, Japan
• Mufaddal Moonim, UK
• Lindsay Oudijk, The Netherlands
• Peter Sadow, USA
• Lester Thompson, USA
• Arthur Tischler, USA
• Gerlof Valk, The Netherlands

Authors of the previous edition of this dataset are available here.