Carcinomas of the Renal Pelvis and Ureter – Nephroureterectomy and Ureterectomy Specimen

Publication History

2nd edition – December 2025

Updated following the publication of the 2022 World Health Organization (WHO) Classification of Urinary and Male Genital Tumours, 5th edition.

This 2nd edition dataset was developed with the kind support of the International Society of Urological Pathology (ISUP).

SUMMARY OF CHANGES

• Updated to Union for International Cancer Control TNM9 staging, including errata published October 2025.
• Revised guide to harmonise with ICCR style for element titles and value list.
• Revised scope for clarity and to harmonise with ICCR style.
• Updated the ‘Clinical information’ element.
• Renamed the ‘Macroscopic tumour site’ element ‘Tumour site’ and updated.
• ‘Tumour focality’ was changed to a non-core element.
• Renamed the ‘Maximum tumour dimension’ element ‘Tumour dimensions’ and changed to a non-core element.
• ‘Macroscopic extent of invasion’ was changed to a non-core element.
• Updated the ‘Histological tumour type’ element to the 5th edition WHO Classification of Urinary and Male Genital Tumours.
• Updated the ‘Non-invasive carcinoma’ element.
• Updated the ‘Histological tumour grade’ element.
• Renamed the ‘Regional lymph node status’ element ‘Lymph node status’ and updated.
• Expanded the ‘Ancillary studies’ element, including adding ‘Representative blocks for ancillary studies’.
• Other minor updates to elements were also included.
• Revised all notes, including incorporation of the 5th edition WHO Classification of Urinary and Male Genital Tumours.

• To reference this dataset please use the following citation: Tsuzuki T, Compérat E, Baydar DE, Cheng L, de Santis M, Downes MR, Hansel DE, Hartmann A, Lopez-Beltran A, Nishiyama H, Ohe C, Pan CC, Reuter VE, Stenzl A, Varma M, Srigley JR (2025). Carcinoma of the Renal Pelvis and Ureter Histopathology Reporting Guide – Nephroureterectomy and Ureterectomy Specimen. 2nd edition. International Collaboration on Cancer Reporting; Sydney, Australia. ISBN: 978-1-922324-75-7.

Expert Committee