Carcinoma of the Renal Pelvis and Ureter - Nephroureterectomy and Ureterectomy Specimen
Four ICCR Datasets for the Urinary Tract have been published. This marks the completion of the ICCR Genitourinary suite of datasets.
The published Urinary Tract datasets are:
Carcinoma of the Bladder - Cystectomy, Cystoprostatectomy and Diverticulectomy Specimen
Carcinoma of the Urethra - Urethrectomy Specimen
Urinary Tract Carcinoma – Biopsy and Transurethral Resection Specimen
The Head and Neck Tumours, WHO Classification of Tumours, 4th Edition, Volume 9
Edited by El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ has been published at the WHO Bookshop
As part of the 4th Edition of the World Health Organisation (WHO) Classification of Tumours, also known as the Blue Book, the new Classification of Head and Neck Tumours was released in 2017. This classification has been incorporated into the suite of 9 datasets developed by the ICCR for Head and Neck, currently out for open consultation.
The ICCR dataset for carcinoma of the Ovary, Fallopian Tube and Primary Peritoneal Site has now been published. Thank you to those who took the time to feed back on the dataset during the public consultation period!
One of the more interesting aspects of this dataset is the recommendations from the expert panel on primary site assignment of high-grade pelvic serous carcinoma (HGSC). There is compelling evidence that the precursors of HGSC originate in the fallopian tube in patients with germline BRCA1 mutations, and accumulating evidence that this is also true for sporadic HGSC. Therefore, in the presence of serous tubal intraepithelial carcinoma (STIC) or invasive HGSC in the tubal mucosa, assignment of a fallopian tube origin is recommended by the expert panel. Suggested criteria are discussed in more detail in the commentary in the published dataset.
Using the published criteria to assign the site of origin of HGSC has obvious implications for cancer registration as the datasets become more widely adopted, with an inevitable increase in fallopian tube cancers and corresponding decrease in ovarian cancers. Because of the downstream impact of this type of change, the ICCR has invited the International Association of Cancer Registries (IACR) to the Dataset Steering Committee to facilitate communication with registries worldwide.
As part of the ICCR development process, a journal article has been written by the expert panel which describes and discusses the evidence behind this and other elements in the ICCR dataset. The article has recently been accepted by Modern Pathology and will be available later in 2015.