Open consultation for the CNS and 9 Head & Neck datasets has commenced. Ten expert panels have overseen the development of these datasets, with a series champion appointed for the suite of Head and Neck datasets. The datasets are available for public comment until Friday 4th May 2018. After this time, each of the expert panels will review the comments and edit the datasets as required. The ICCR Dataset Steering Committee will finally approve the datasets for publication.
The Head and Neck Tumours, WHO Classification of Tumours, 4th Edition, Volume 9
Edited by El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ has been published at the WHO Bookshop
As part of the 4th Edition of the World Health Organisation (WHO) Classification of Tumours, also known as the Blue Book, the new Classification of Head and Neck Tumours was released in 2017. This classification has been incorporated into the suite of 9 datasets developed by the ICCR for Head and Neck, currently out for open consultation.
The ICCR dataset for carcinoma of the Ovary, Fallopian Tube and Primary Peritoneal Site has now been published. Thank you to those who took the time to feed back on the dataset during the public consultation period!
One of the more interesting aspects of this dataset is the recommendations from the expert panel on primary site assignment of high-grade pelvic serous carcinoma (HGSC). There is compelling evidence that the precursors of HGSC originate in the fallopian tube in patients with germline BRCA1 mutations, and accumulating evidence that this is also true for sporadic HGSC. Therefore, in the presence of serous tubal intraepithelial carcinoma (STIC) or invasive HGSC in the tubal mucosa, assignment of a fallopian tube origin is recommended by the expert panel. Suggested criteria are discussed in more detail in the commentary in the published dataset.
Using the published criteria to assign the site of origin of HGSC has obvious implications for cancer registration as the datasets become more widely adopted, with an inevitable increase in fallopian tube cancers and corresponding decrease in ovarian cancers. Because of the downstream impact of this type of change, the ICCR has invited the International Association of Cancer Registries (IACR) to the Dataset Steering Committee to facilitate communication with registries worldwide.
As part of the ICCR development process, a journal article has been written by the expert panel which describes and discusses the evidence behind this and other elements in the ICCR dataset. The article has recently been accepted by Modern Pathology and will be available later in 2015.
The Dataset Steering Committee (DSC)
of the ICCR which has responsibility for all activities relating to the development of ICCR cancer datasets, has recently invited the International Association of Cancer Registries (IACR) to join its membership.
With its overarching view of cancer registration across the globe and as secondary users of cancer data, the IACR and its members are uniquely placed to provide a significant contribution to the ICCR.