The ICCR dataset for carcinoma of the Ovary, Fallopian Tube and Primary Peritoneal Site has now been published. Thank you to those who took the time to feed back on the dataset during the public consultation period!
One of the more interesting aspects of this dataset is the recommendations from the expert panel on primary site assignment of high-grade pelvic serous carcinoma (HGSC). There is compelling evidence that the precursors of HGSC originate in the fallopian tube in patients with germline BRCA1 mutations, and accumulating evidence that this is also true for sporadic HGSC. Therefore, in the presence of serous tubal intraepithelial carcinoma (STIC) or invasive HGSC in the tubal mucosa, assignment of a fallopian tube origin is recommended by the expert panel. Suggested criteria are discussed in more detail in the commentary in the published dataset.
Using the published criteria to assign the site of origin of HGSC has obvious implications for cancer registration as the datasets become more widely adopted, with an inevitable increase in fallopian tube cancers and corresponding decrease in ovarian cancers. Because of the downstream impact of this type of change, the ICCR has invited the International Association of Cancer Registries (IACR) to the Dataset Steering Committee to facilitate communication with registries worldwide.
As part of the ICCR development process, a journal article has been written by the expert panel which describes and discusses the evidence behind this and other elements in the ICCR dataset. The article has recently been accepted by Modern Pathology and will be available later in 2015.
The Dataset Steering Committee (DSC)
of the ICCR which has responsibility for all activities relating to the development of ICCR cancer datasets, has recently invited the International Association of Cancer Registries (IACR) to join its membership.
With its overarching view of cancer registration across the globe and as secondary users of cancer data, the IACR and its members are uniquely placed to provide a significant contribution to the ICCR.
The World Health Organisation (WHO) Classification of Tumours of Lung, Pleura, Thymus and Heart fourth edition
, editors Travis, W.D., Brambilla, E., Burke, A.P., Marx, A., and Nicholson, A. G. has now been published at the WHO Bookshop
This latest edition is the driver for the new Thoracic suite of datasets currently being developed which includes datasets for Heart, Thymus, Mesothelioma and an update to the existing Lung cancer dataset.